BDBM50370609 CHEMBL4177497::US10954217, Example 00230

SMILES CC(=C)CN1CCN(CC1)c1ccc2CN(Cc2c1)C(=O)OCc1ccccc1

InChI Key InChIKey=IWCOVZWJPVWEFW-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50370609   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  92nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  153nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  153nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetHistamine H1 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  298nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  1.02E+3nMAssay Description:Displacement of [3H]-alpha-methylhistamine from human histamine H3 receptor expressed in HEK Flp-In cells after 90 mins by microbeta scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]-Pindolol from human adrenergic beta1 receptor expressed in Flp-In CHO cells after 90 mins by microbeta scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370609(CHEMBL4177497 | US10954217, Example 00230)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-iodoaminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed