BDBM50370627 CHEMBL4169689::US10954217, Example 00243

SMILES CCOC(=O)CCN1CCN(CC1)c1ccc2CCN(Cc2c1)C(=O)OCc1ccccc1

InChI Key InChIKey=HLXXHUQBOMNXCU-UHFFFAOYSA-N

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50370627   

TargetHistamine H1 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  198nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  198nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  335nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  407nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  475nMAssay Description:Displacement of [3H]-Ketanserin from human 5-HT2A receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  507nMAssay Description:Displacement of [125I]-iodoaminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  908nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  1.06E+3nMAssay Description:Displacement of [3H]-Nisoxetine from human NET receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  1.67E+3nMAssay Description:Displacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  2.44E+3nMAssay Description:Displacement of [3H]-5-CT from human 5-HT1B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  2.59E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M5 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  2.96E+3nMAssay Description:Displacement of [3H]-Win35428 from human DAT expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi:  3.52E+3nMAssay Description:Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370627(CHEMBL4169689 | US10954217, Example 00243)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-LSD from human 5-HT5A receptor expressed in Flp-In CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed