BDBM50376358 CHEMBL259013

SMILES Nc1ncnc2NCCC(=Nc12)c1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=GACBELOLIOXYRT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50376358   

TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50376358(CHEMBL259013)
Affinity DataIC50: 110nMAssay Description:Inhibition of KDR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50376358(CHEMBL259013)
Affinity DataIC50: 9nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50376358(CHEMBL259013)
Affinity DataIC50: 35nMAssay Description:Inhibition of cKitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50376358(CHEMBL259013)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed