BDBM50377347 CHEMBL404640

SMILES COc1ccc(-c2cc(C)c3NC(C)(C)CC(C)c3c2Cl)c2[nH]ccc12

InChI Key InChIKey=NZGNOGXYEWYRJB-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50377347   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377347(CHEMBL404640)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377347(CHEMBL404640)
Affinity DataKi:  110nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377347(CHEMBL404640)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at glucocorticoid receptor assessed as glucose response element transcriptional transactivation by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377347(CHEMBL404640)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377347(CHEMBL404640)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity at progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed