BDBM50379268 CHEMBL3216556

SMILES [H][C@]12Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5CCCCc5nc5cc(Cl)ccc45)c3[C@]([H])(CC(C)=C1)C2

InChI Key InChIKey=GCPORJYZTJZXFH-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50379268   

TargetBeta-secretase 1(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human recombinant BACE-1 using M-2420 as substrate preincubated for 1 hr prior substrate addition measured after 15 mins by spectrofluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataIC50: 86.8nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataIC50: 87nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed