BDBM50379274 CHEMBL2011499::US9238626, (+)-Huprine Y HCl

SMILES CC1=C[C@@H]2C[C@H](C1)c1c(C2)nc2cc(Cl)ccc2c1N

InChI Key InChIKey=UKCBMHDZLYYTMI-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50379274   

TargetAcetylcholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 13.6nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellman ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetCholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 170nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by the method of Ellman et al., using 0.02 unit/mL of human serum BChE and 300 uM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:β-Secretase (BACE-1, Sigma) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (methoxycoumarin-Ser-Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetAcetylcholinesterase(Electric eel)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 373nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellman ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
Go to US Patent

TargetAcetylcholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 321nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 170nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant mouse sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 474nMAssay Description:Inhibition of recombinant mouse AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50: 321nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed