BDBM50380938 CHEMBL2016891

SMILES COC(=O)c1cc(NCCN2CCCC2)c(C)c(c1)N1CCN(CC1)c1ncnc2n[nH]c(Br)c12

InChI Key InChIKey=UUZYXVMMMLOUNS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50380938   

TargetRibosomal protein S6 kinase beta-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50: 2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT1 after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50: 44nMAssay Description:Inhibition of p70S6K-mediated ribosomal protein S6 phosphorylation in human A549 cells after 3 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50: 52nMAssay Description:Inhibition of p70S6K-mediated ribosomal protein S6 phosphorylation in human PC3 cells after 3 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of AKT1-mediated GSK3beta phosphorylation in human PC3 cells after 3 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed