BDBM50381698 CHEMBL1969102::US8722890, 6

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cn[nH]c2)c1

InChI Key InChIKey=UGEJLCNSVIVALC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50381698   

LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 2.18nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
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LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 1.90nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 2.74nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 1.81nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 4.28nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 8.44nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
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TargetAurora kinase A(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 357nMpH: 7.4Assay Description:To determine Aurora A and C activity of representative compounds of the invention, Active Aurora A or C enzyme was incubated in wells of a 384 well p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
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TargetCytochrome P450 3A4(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 300nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
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TargetCytochrome P450 3A4(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 760nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR using 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbvie

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 8nMAssay Description:Inhibition of Aurora B using 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 14nMAssay Description:Inhibition of human KDR phosphorylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed