BDBM50383044 CHEMBL2031311::US10774068, Example 96::US11427560, Example 96

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)CCN(C)C

InChI Key InChIKey=FVHRPBPPQDUXSJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50383044   

TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50383044(CHEMBL2031311 | US10774068, Example 96 | US1142756...)
Affinity DataIC50: 12.5nMAssay Description:Inhibition of human recombinant EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate after 15 mins by time-resolved fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 4(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50383044(CHEMBL2031311 | US10774068, Example 96 | US1142756...)
Affinity DataIC50: 100nMAssay Description:MST1 and MST2 biochemical LanthaScreen Eu Kinase Binding Assay was based on the binding and displacement of kinase tracer to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase 4(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50383044(CHEMBL2031311 | US10774068, Example 96 | US1142756...)
Affinity DataIC50: 100nMAssay Description:MST1 and MST2 biochemical LanthaScreen Eu Kinase Binding Assay was based on the binding and displacement of kinase tracer to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50383044(CHEMBL2031311 | US10774068, Example 96 | US1142756...)
Affinity DataIC50: 970nMAssay Description:Inhibition of ErbB2 by time-resolved fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed