BindingDB BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002

BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002

SMILES CN1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)Oc4cccc(c4)NC(=O)C=C)Cl

InChI Key InChIKey=ITTRLTNMFYIYPA-UHFFFAOYSA-N

Data 58 IC50 27 Kd 6 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 91 hits for monomerid = 50383274

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 1.20nMAssay Description:Binding affinity to wild type partial length human EGFR expressed in bacterial system by KINOMEscan assayMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
Entry Details Article
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3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 300nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2.24E+5nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair

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Date in BDB:
4/23/2024
Entry Details
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 7.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair

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Date in BDB:
4/23/2024
Entry Details
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3D Structure (crystal)

NUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 25nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair

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Date in BDB:
6/18/2023
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 4.60nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant EGFR L858R mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE ...More data for this Ligand-Target Pair

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Date in BDB:
8/20/2022
Entry Details Article
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2.90nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant EGFR L861Q mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE ...More data for this Ligand-Target Pair

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Date in BDB:
8/20/2022
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant EGFR T790M mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE ...More data for this Ligand-Target Pair

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Date in BDB:
8/20/2022
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 4.60nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system by Z'...More data for this Ligand-Target Pair

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Date in BDB:
8/20/2022
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 0.800nMAssay Description:Inhibition of recombinant human N-terminal GST tagged EGFR L858R mutant (669 to 1210 residues) expressed in insect expression system using peptide as...More data for this Ligand-Target Pair

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Date in BDB:
3/27/2022
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 0.0400nMAssay Description:Inhibition of recombinant human N-terminal GST tagged EGFR L858R/T790M double mutant (669 to 1210 residues) expressed in insect expression system usi...More data for this Ligand-Target Pair

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Date in BDB:
3/27/2022
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 0.300nMAssay Description:Binding affinity to partial length human EGFR L858R/T790M double mutant expressed in mammalian system by KINOMEscan assayMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

NUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 91nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 0.300nMAssay Description:Binding affinity to partial length human EGFR L858R/T790M double mutant expressed in mammalian system by KINOMEscan assayMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 1.20nMAssay Description:Binding affinity to wild type partial length human EGFR expressed in bacterial system by KINOMEscan assayMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 1.70nMAssay Description:Inhibition of EGFR (unknown origin) using biotin-labelled peptide as substrate preincubated for 2 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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3D Structure (crystal)

Dipeptidyl peptidase 1(Human)
National Institute of Biological Sciences (Nibs)

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2.10E+3nMAssay Description:Inhibition of cathepsin C (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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Dipeptidyl peptidase 1(Human)
National Institute of Biological Sciences (Nibs)

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2.10E+3nMAssay Description:Inhibition of CatL-activated recombinant human C-terminal His10-tagged cathepsin C (25 to 463 residues) expressed in mouse myeloma cells using Gly-Ph...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Harvard Medical School

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

EC50: 6.26E+3nMAssay Description:Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

EC50: 27nMAssay Description:Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after...More data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

EC50: 68nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MT...More data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

EC50: 26nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 4nMAssay Description:Inhibition of GST-tagged human EGFR T790M/L858R double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system us...More data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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3D Structure (crystal)

eIF-2-alpha kinase GCN2(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 140nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase JAK3(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 2.82E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase JAK2(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 3.76E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase Blk(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 756nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Cytoplasmic tyrosine-protein kinase BMX(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 48nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 7.56E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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3D Structure (crystal)

NUAK family SNF1-like kinase 2(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 10nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Focal adhesion kinase 1(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 78nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Serine/threonine-protein kinase PLK4(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 100nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase JAK3(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 150nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase ITK/TSK(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 43nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Cyclin-G-associated kinase(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 91nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

EC50: 31nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
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3D Structure (crystal)

Receptor-type tyrosine-protein kinase FLT3(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 33nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Receptor tyrosine-protein kinase erbB-4(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 28nMMore data for this Ligand-Target Pair

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Date in BDB:
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Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 29nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 28nMMore data for this Ligand-Target Pair

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Date in BDB:
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 14nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 12nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 46nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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3D Structure (crystal)

Serine/threonine-protein kinase DCLK3(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 910nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase BTK(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 36nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Tyrosine-protein kinase Blk(Human)
Institute

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

Kd: 220nMMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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Epidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 1.02nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair

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Date in BDB:
7/7/2018
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3D Structure (crystal)

Epidermal growth factor receptor(Human)
Dalian Medical University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 8.60E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
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3D Structure (crystal)

Tyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 1.63E+4nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
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PubMed

Tyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL

BDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)

IC50: 9.69E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed

Displayed 1 to 50 (of 91 total ) | Next | Last >>

Filter my 91 hits

Targets 23▿
- Epidermal growth factor receptor 62
- Tyrosine-protein kinase JAK3 3
- Dipeptidyl peptidase 1 2
- Tyrosine-protein kinase ABL1 2
- ALK tyrosine kinase receptor 2
- Tyrosine-protein kinase Blk 2
- NUAK family SNF1-like kinase 1 2
- Receptor-type tyrosine-protein kinase FLT3 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Epidermal growth factor receptor [L858R] 1
- Cyclin-G-associated kinase 1
- Serine/threonine-protein kinase PLK4 1
- Tyrosine-protein kinase BTK 1
- ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 1
- Tyrosine-protein kinase ITK/TSK 1
- Epidermal growth factor receptor [1-745,751-1210] 1
- Receptor tyrosine-protein kinase erbB-4 1
- eIF-2-alpha kinase GCN2 1
- Focal adhesion kinase 1 1
- Serine/threonine-protein kinase DCLK3 1
- Tyrosine-protein kinase JAK2 1
- Epidermal growth factor receptor [T790M,L858R] 1
- NUAK family SNF1-like kinase 2 1
Publications 26▿
- Nature 462: 1070-4 24
- Eur J Med Chem 136: 497-510 (2017) 10
- Bioorg Med Chem Lett 27: 4832-4837 (2017) 5
- J Med Chem 59: 6580-94 (2016) 4
- Eur J Med Chem 211: (2021) 4
- Bioorg Med Chem Lett 28: 1257-1261 (2018) 4
- Bioorg Med Chem 23: 2767-80 (2015) 3
- J Med Chem 62: 5901-5919 (2019) 3
- J Med Chem 56: 7821-37 (2013) 3
- J Med Chem 56: 7025-48 (2013) 3
- J Med Chem 56: 4738-48 (2013) 3
- US Patent US9670213 (2017) 3
- J Med Chem 60: 7725-7744 (2017) 3
- US Patent US10167264 (2019) 2
- Eur J Med Chem 140: 510-527 (2017) 2
- Eur J Med Chem 104: 115-26 (2015) 2
- Bioorg Med Chem 24: 2673-80 (2016) 2
- J Med Chem 55: 2711-23 (2012) 2
- Bioorg Med Chem 26: 1740-1750 (2018) 2
- J Med Chem 60: 4636-4656 (2017) 1
- Eur J Med Chem 77: 75-83 (2014) 1
- J Med Chem 60: 5613-5637 (2017) 1
- J Med Chem 64: 2-25 (2021) 1
- Eur J Med Chem 66: 82-90 (2013) 1
- J Med Chem 58: 6844-63 (2015) 1
- J Med Chem 58: 6589-606 (2015) 1
Institutions 21▿
- Institute 24
- Harvard Medical School 11
- China Pharmaceutical University 9
- St. John'S University 5
- Tu Dortmund University 4
- Shanghai Haiyan Pharmaceutical Technology Co. Itd. 4
- Dalian Medical University 4
- National Institute of Biological Sciences (Nibs) 3
- Astrazeneca 3
- Technische Universit£T Dortmund 3
- East China University of Science and Technology 3
- East China University of Science & Technology 3
- Chinese Academy of Sciences 2
- Beijing Normal University 2
- Nanjing University of Science and Technology 2
- Fudan University 2
- Jiangsu Medolution 2
- Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) 2
- University of Science and Technology (Ust) 1
- Eberhard Karls Universit£T T£Bingen 1
- Eberhard Karls University T£Bingen 1
Affinity: 0.040 to 2.2E+5 nM▿
- IC50 58
- Kd 27
- EC50 6
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1