BDBM50387053 CHEMBL2047035

SMILES CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COC\C=C\CCCNC(=O)c3cc(cc(c3)C(=O)N2)N(C)S(C)(=O)=O)c1

InChI Key InChIKey=PDQRIFLZLJPPAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50387053   

TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50387053(CHEMBL2047035)
Affinity DataIC50: 180nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) cells using Swedish mutant sequence Eu-EVNLDAEFK-quencher at 10 uM after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50387053(CHEMBL2047035)
Affinity DataIC50: 73nMAssay Description:Inhibition of BACE1 expressed in human HEK293 cells expressing Swedish mutant APP assessed as reduction on amyloid beta (1 to 40) production after 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed