BDBM50387586 CHEMBL2057731::US8633204, 208

SMILES CC(C)n1c2nc(N)nc(C)c2cc(-c2cn[nH]c2)c1=O

InChI Key InChIKey=SBGOBTVWKFJHKH-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50387586   

LigandPNGBDBM50387586(CHEMBL2057731 | US8633204, 208)
Affinity DataIC50: 29.4nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent

LigandPNGBDBM50387586(CHEMBL2057731 | US8633204, 208)
Affinity DataKi:  13.5nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387586(CHEMBL2057731 | US8633204, 208)
Affinity DataKi:  23.5nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed