BDBM50387588 CHEMBL2057728::US8633204, 205

SMILES Cc1nc(N)nc2n(C3CCC3)c(=O)c(cc12)-c1cn[nH]c1

InChI Key InChIKey=XDXSZXPYYXPVRA-UHFFFAOYSA-N

Data  2 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50387588   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pfizer

US Patent

LigandBDBM50387588(CHEMBL2057728 | US8633204, 205)Copy SMILESCopy InChI

Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/6/2014
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50387588(CHEMBL2057728 | US8633204, 205)Copy SMILESCopy InChI

Affinity DataKi:  7nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50387588(CHEMBL2057728 | US8633204, 205)Copy SMILESCopy InChI

Affinity DataKi:  51.2nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL