BDBM50387590 CHEMBL2057725::US8633204, 111

SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=CKLJHQGTKDVDQX-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50387590   

LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataIC50: 2.96nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTOR (unknown origin) after 40 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincubated for 15 mins by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataKi:  1.56nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataKi:  142nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed