BDBM50389177 CHEMBL2062795

SMILES CS(=O)(=O)c1cccc(c1)-c1cccn2nc(Nc3ccccc3)nc12

InChI Key InChIKey=WDNHLKQUQTYIIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50389177   

TargetTyrosine-protein kinase JAK2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389177(CHEMBL2062795)
Affinity DataIC50: 8nMAssay Description:Inhibition of human JAK2 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389177(CHEMBL2062795)
Affinity DataIC50: 475nMAssay Description:Inhibition of human JAK3 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389177(CHEMBL2062795)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of JAK2 in human TF-1 cells using GM-CSF pretreated for 1 hr prior to GM-CSF addition measured after 5 hrs by FRET based GeneBLAzer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed