BDBM50393016 CHEMBL2152681::US9656959, Example 3

SMILES CC(C)C[C@H](NC(C)=O)C(=O)Nc1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1

InChI Key InChIKey=KVVOUURXKOZNPC-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393016   

LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataIC50: 42nMAssay Description:Blockade of Nav1.7 by FLIPR TETRA sodium dye assay in presence of KCl saltMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataIC50: 42nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent

LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataKi:  194nMAssay Description:Blockade of Nav1.7 by electrophysiological patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393016(CHEMBL2152681 | US9656959, Example 3)
Affinity DataKi:  194nMAssay Description:In the alternative, the voltage clamp protocol to examine hNav1.7 currents was as follows. First, the standard current-voltage relationship was teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
Go to US Patent