BDBM50393785 CHEMBL2159341

SMILES C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(cc1-c1ccc2cc(C)ccc2c1)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=KNTOEHKTBLUGLN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393785   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393785(CHEMBL2159341)
Affinity DataIC50: 4.60nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393785(CHEMBL2159341)
Affinity DataIC50: 753nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393785(CHEMBL2159341)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50393785(CHEMBL2159341)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed