BDBM50394629 CHEMBL2164596::US9169224, 60

SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1

InChI Key InChIKey=FERHPCZABHYPHY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50394629   

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 9nMpH: 9.0Assay Description:Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 6nMAssay Description:Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 298nMAssay Description:Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 300nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 6nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 300nMAssay Description:Inhibition of rat FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Affinity DataIC50: 6nMAssay Description:Inhibition of human FAAH preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed