BDBM50394897 CHEMBL2165498

SMILES CN(C)C1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-n2c(C)nc3ccccc23)CC1

InChI Key InChIKey=LJTQAIKAEMCJSG-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50394897   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394897(CHEMBL2165498)Copy SMILESCopy InChI

Affinity DataIC50: 2.70nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394897(CHEMBL2165498)Copy SMILESCopy InChI

Affinity DataIC50: 374nMAssay Description:Inhibition of human PI3Kdelta-mediated AKT phosphorylation at S473 in Ri-1 cells after 30 mins by electrochemiluminescence assay in presence of human...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394897(CHEMBL2165498)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL