BDBM50397225 CHEMBL2172778

SMILES Clc1ccc(cc1)C#Cc1ccc(cc1)-c1nn(cc1CC(=O)NS(=O)(=O)c1ccc(Cl)cc1)-c1ccccc1

InChI Key InChIKey=KPNKOAZGTGSBGD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397225   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50397225(CHEMBL2172778)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human neutrophils assessed as inhibition of enzyme product formation by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50397225(CHEMBL2172778)
Affinity DataIC50: 350nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed