BDBM50397937 CHEMBL2179539

SMILES Cc1ccoc1C(=O)N1CC2CNCC2C1

InChI Key InChIKey=XCORZZYKCQYSQJ-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50397937   

LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR in human SH-EP1 cells assessed as calcium flux by calcium4-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]nicotine from alpha4beta2 nAChR in human SH-EP1 cells after 2 hrs by liquid scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataKi:  44nM ΔG°:  -9.89kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Targacept

US Patent
LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataKi:  54nM ΔG°:  -9.77kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha7 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50397937(CHEMBL2179539)
Affinity DataKi:  2.50E+4nM ΔG°:  -6.19kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
Go to US Patent