BDBM50399015 CHEMBL2178804

SMILES Cn1cc(NC(=O)c2cnn3ccc(N)nc23)c(n1)-c1cc(Cl)ccc1Cl

InChI Key InChIKey=NNGCTIVKZKXWGS-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50399015   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as reduction in STAT5 phosphorylation incubated for 30 mins in presence of human recombinant EPOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 5.80E+3nMAssay Description:Time dependent inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of ROSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataIC50: 4.97E+3nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399015(CHEMBL2178804)
Affinity DataKi:  0.100nMAssay Description:Inhibition of purified JAK2 incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed