BDBM50400097 CHEMBL2177118::US12630497, Compound 9-1

SMILES COC(=O)c1cccc(NC(=O)CCOc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1

InChI Key InChIKey=DCWZGVZXOAEXSK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50400097   

TargetHypoxia-inducible factor 1-alpha(Human)
Dongguk University-Seoul

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400097BDBM50400097(CHEMBL2177118 | US12630497, Compound 9-1)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMalate dehydrogenase, cytoplasmic(Human)
Dongguk University Industry-Academic Cooperation Foundation

US Patent
LigandChemical structure of BindingDB Monomer ID 50400097BDBM50400097(CHEMBL2177118 | US12630497, Compound 9-1)
Affinity DataIC50: 3.00E+3nMAssay Description:Human V1b receptor was transiently expressed in 293FT cells (Invitrogen). The cells were collected and then homogenated in a 15 mmol/L tris-hydrochlo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetMalate dehydrogenase, mitochondrial(Human)
Dongguk University Industry-Academic Cooperation Foundation

US Patent
LigandChemical structure of BindingDB Monomer ID 50400097BDBM50400097(CHEMBL2177118 | US12630497, Compound 9-1)
Affinity DataIC50: 7.50E+3nMAssay Description:Human V1b receptor was transiently expressed in 293FT cells (Invitrogen). The cells were collected and then homogenated in a 15 mmol/L tris-hydrochlo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent