BDBM50400302 CHEMBL2181313

SMILES COc1ccc-2cc1COCC=CCOCc1cc(Nc3nccc-2n3)ccc1OCCN1CCCC1

InChI Key InChIKey=HLNMMXYNDBSAPI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50400302   

TargetTyrosine-protein kinase JAK3(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 890nMAssay Description:Inhibition of recombinant JAK3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK1 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant JAK2 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as decrease in formation of dextrorphan from dextromethorphan substrate after 30 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as decrease in formation of 1-hydroxymidazolam from midazolam substrate after 5 mins by LC-MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant FLT3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400302(CHEMBL2181313)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed