BDBM50400890 CHEMBL2204356

SMILES Clc1cccc(Sc2ccccc2N2CCNCC2)c1Cl

InChI Key InChIKey=ZSDSOMKIKNSFJG-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50400890   

TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 17nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 21nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using resorufin benzyl ether after 30 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant CYP2D6 using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy- 4-methylcoumarin after 45 mins by fluorescence spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9 using dibenzylfluorescein after 45 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human recombinant CYP1A2 using 7-ethoxy-3-cyanocoumarin after 28 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]5-carboxamidotryptamine to human 5HT1A expressed in HEK293 cells by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed