BDBM50402168 CHEMBL2208237

SMILES CC(C)COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1

InChI Key InChIKey=FMPROYAQAQOEAE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50402168   

TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)
Affinity DataIC50: 36nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402168(CHEMBL2208237)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed