BDBM50405792 CHEMBL5281791

SMILES CNCc1cc(F)c(c(OC)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1

InChI Key InChIKey=GUUQXMDBAHSFGF-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50405792   

TargetMast/stem cell growth factor receptor Kit(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 857nMAssay Description:Inhibition of KIT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 260nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 330nMAssay Description:Inhibition of TrkA (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataIC50: 219nMAssay Description:Inhibition of human HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405792(CHEMBL5281791)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant human HPK1 (1 to 346 residues) expressed sf9 cells incubated for 1 hr by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed