BDBM50406127 CHEMBL5290844::US20250026762, Compound 7

SMILES Fc1ccc(cc1Cl)-c1nn(C(=O)N2CCN3CCC2CC3)c2COCCc12

InChI Key InChIKey=DGNGVHCQYLRMQR-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50406127   

TargetCeramide glucosyltransferase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406127(CHEMBL5290844 | US20250026762, Compound 7)
Affinity DataIC50: 1nMAssay Description:Inhibition of Glucosylceramide synthase (unknown origin) using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide glucosyltransferase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406127(CHEMBL5290844 | US20250026762, Compound 7)
Affinity DataEC50:  1nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent