BDBM50406134 CHEMBL5275403

SMILES Cl.FC(F)(F)c1cnn(c1)-c1nn(C(=O)N2CCN3CCC2CC3)c2COCCc12

InChI Key InChIKey=SGWGAPZBWBNLGK-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50406134   

TargetCeramide glucosyltransferase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 32nMAssay Description:Inhibition of GCS in human fibroblastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 1.97E+3nMAssay Description:Antagonist activity at human 5HT3A expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide glucosyltransferase(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 17nMAssay Description:Inhibition of GCS in mouse fibroblastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCeramide glucosyltransferase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GCS in human iPSC derived neurons assessed as reduction in brain GlcCer levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed