BDBM50417844 CHEMBL1667963

SMILES c1cc2c(ccnc2N)c(c1)S(=O)(=O)N3CCCNCC3

InChI Key InChIKey=QITCSTCJTLZZMU-UHFFFAOYSA-N

Data  1 KI  8 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50417844   

TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of ROCK1 by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human PrkX by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PKCeta by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of ROCK1 in human THP cells assessed as inhibition of MCP1-induced cell migrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 575nMAssay Description:Inhibition of ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human PKCdelta by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 759nMAssay Description:Inhibition of ROCK1 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKCmu by RFBA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataKi:  34.7nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed