BDBM50418600 CHEMBL1784165

SMILES Cc1c(Cl)cc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1

InChI Key InChIKey=FFENCJNTMAOQOD-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50418600   

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418600(CHEMBL1784165)
Affinity DataIC50: 158nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418600(CHEMBL1784165)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418600(CHEMBL1784165)
Affinity DataKi:  12.6nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed