BDBM50419331 CHEMBL1911969

SMILES CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccc(F)cc1C)C1CC(=O)NC1CO

InChI Key InChIKey=ZDVCPNJSRCVCHL-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50419331   

TargetSubstance-P receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  0.251nMAssay Description:Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  0.251nMAssay Description:Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in human U20S cells assessed as effect on NKB-induced intracellular calcium level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in human U20S cells assessed as effect on NKB-induced intracellular calcium level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in human U20S cells assessed as effect on NKB-induced intracellular calcium level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419331(CHEMBL1911969)
Affinity DataKi:  794nMAssay Description:Antagonist activity at human recombinant NK3 receptor expressed in human U20S cells assessed as effect on NKB-induced intracellular calcium level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed