BDBM50419338 CHEMBL1446457

SMILES COc1ccccc1C1(O)CCN(CCCn2c3ccccc3c3ccccc23)CC1

InChI Key InChIKey=XZZYCJOGZYEPPW-UHFFFAOYSA-N

Data  4 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50419338   

TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 8.92E+3nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of mouse mGAT3 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of mouse mGAT4 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of mouse mGAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of mouse mGAT2 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of mouse BGT1 expressed in hamster BHK cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2019
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of mouse GAT3 expressed in hamster BHK cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2019
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of mouse GAT1 expressed in hamster BHK cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2019
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig-Maximilians-University Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataKi:  4.10E+4nMAssay Description:Inhibition of mouse GAT2 expressed in hamster BHK cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2019
Entry Details Article
PubMed