BDBM50421578 CHEMBL13789

SMILES C(Oc1ccccc1-c1ccccc1)C1=NCCN1

InChI Key InChIKey=BPRZPBVOIULUSI-UHFFFAOYSA-N

Data  4 KI  6 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50421578   

TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50:  3.20nMAssay Description:Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50: <1.00E+5nMAssay Description:Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50: <1.00E+5nMAssay Description:Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50: <1.00E+5nMAssay Description:Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50:  3.20nMAssay Description:Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataEC50: <1.00E+5nMAssay Description:Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro binding affinity against cloned human alpha-1B-adrenoceptor receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 550nMAssay Description:In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 66nMAssay Description:In vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 741nMAssay Description:Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 324nMAssay Description:Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataIC50: 28nMAssay Description:Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetNischarin(Rat)TBA
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A/B(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataKi:  302nMAssay Description:Displacement of [3H]idazoxan from imidazoline receptor I-2 binding sites in rabbit kidney membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNischarin(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50421578(CHEMBL13789)
Affinity DataKi:  316nMAssay Description:Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed