BDBM50424746 CHEMBL2314178::US10093640, Example 8::US10844032, Example 8

SMILES Cc1cc(OCCCc2c(sc3c(Cl)cccc23)C(O)=O)cc(C)c1Cl

InChI Key InChIKey=HPLRRUUZIYNNGV-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50424746   

LigandPNGBDBM50424746(CHEMBL2314178 | US10093640, Example 8 | US10844032...)
Affinity DataIC50: 750nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
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LigandPNGBDBM50424746(CHEMBL2314178 | US10093640, Example 8 | US10844032...)
Affinity DataKi:  750nMAssay Description:Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50424746(CHEMBL2314178 | US10093640, Example 8 | US10844032...)
Affinity DataKi:  750nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent