BDBM50425045 CHEMBL2312896::CHEMBL2322964::US9402842, 43

SMILES NCCCn1c2-c3ccccc3C(=O)c2c2ccc(NCC(O)=O)cc2c1=O

InChI Key InChIKey=ZKDKMZHAOXZKID-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50425045   

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425045(CHEMBL2322964 | CHEMBL2312896 | US9402842, 43)
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Tdp1 reactions were performed as recently described. Briefly, a 5'-[32P]-labeled single-stranded DNA oligonucleotide containing a 3'-phosphotyrosine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
Go to US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425045(CHEMBL2322964 | CHEMBL2312896 | US9402842, 43)
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:A 5′-[32P]-labeled single-stranded DNA oligonucleotide containing a 3′-phosphotyrosine (N14Y) was generated as described by Dexheimer et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425045(CHEMBL2322964 | CHEMBL2312896 | US9402842, 43)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50425045(CHEMBL2322964 | CHEMBL2312896 | US9402842, 43)
Affinity DataEC50:  8.40E+3nMAssay Description:Activation of human RXRalpha activity expressed in COS1 cells after 12 hrs by RXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed