BDBM50426734 CHEMBL2322142

SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12

InChI Key InChIKey=DRLXSJUOTKNTDH-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50426734   

TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataEC50:  150nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataIC50: 240nMAssay Description:Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426734(CHEMBL2322142)
Affinity DataIC50: 40nMAssay Description:Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed