BDBM50426737 CHEMBL2322137

SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12

InChI Key InChIKey=MNRAJFUSWSJXCI-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50426737   

TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataEC50:  430nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 30nMAssay Description:Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 570nMAssay Description:Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426737(CHEMBL2322137)
Affinity DataIC50: 60nMAssay Description:Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed