BDBM50428126 CHEMBL2331676

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2CN(CCc2c(n1)N1CCOC[C@@H]1C)c1cc(C)ncn1

InChI Key InChIKey=JFXLXTLDGUAURJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428126   

TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50428126(CHEMBL2331676)
Affinity DataKi:  2.70nMAssay Description:Inhibition of recombinant mTOR (1360 to 2549)+GBL (unknown origin) using GFP-4E-BP1 as substrate after 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50428126(CHEMBL2331676)
Affinity DataIC50: 8.40E+3nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsome using midazolam as substrate by TDI shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed