BDBM50431075 CHEMBL2338789::US10202399, Example 40::US10463663, Example 13::US11129828, Example 13::US9290456, 13::US9931340, Example 13

SMILES Oc1cc(CCC2CCCCC2)n[nH]c1=O

InChI Key InChIKey=XOTMJYKZULIBIT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50431075   

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Mouse)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 4.70nMAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 31nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 31nMAssay Description:The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431075(CHEMBL2338789 | US9290456, 13 | US10202399, Exampl...)
Affinity DataIC50: 31nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent