BDBM50431134 CHEMBL2332068

SMILES COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=KACIGJBSABVNRF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431134   

TargetRho-associated protein kinase 2(Human)
Shanghai Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Shanghai Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK1 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)-mediated bufuralol hydroxylation to 4'-HydroxybufuralolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Shanghai Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)-mediated midazolam hydroxylation to 1'-HydroxymidazolamMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)-mediated tolbutamide hydroxylation to hydroxy tolbutamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)-mediated phenaceten demethylation to acetaminophenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of MRCKalpha (unknown origin) using LCD-AKRRRRLSSLRA-NH2 as substrate after 75 mins by luminescence assay in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50431134(CHEMBL2332068)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of JNK3 alpha1 (unknown origin) using biotinylated Flag-ATF2 as substrate after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed