BDBM50431886 CHEMBL1413473

SMILES CC(=O)NC1=NN(C(C)=O)C(C)(S1)c1ccccc1

InChI Key InChIKey=JEFVYQYZCAVNTP-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50431886   

TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Eg5 in human HCT116 cells assessed as inhibition of microtubule-induced ATPase activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 800nMAssay Description:Inhibition of MT-stimulated EG5 ATPase activity (unknown origin) by pyruvate kinase/lactate dehydrogenase enzyme coupled photometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition EG5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant BChE using butyrylthiocholine as substrate preincubated for 300 secs followed by substrate addition and measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 740nMAssay Description:Inhibition of N-terminal His6-tagged microtubule-stimulated ATPase activity of human Eg5 motor domain (1 to 368 residues) expressed in Escherichia co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 740nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataKd:  665nMAssay Description:Binding affinity to N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Kyowa Hakko Kirin

Curated by ChEMBL
LigandPNGBDBM50431886(CHEMBL1413473)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of microtubule-stimulated recombinant human Eg5 ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed