BDBM50432397 CHEMBL2348989

SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CCOCC4)cn3n2)c1

InChI Key InChIKey=WFIZKEJDQNESRZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50432397   

TargetSerine/threonine-protein kinase B-raf(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50432397(CHEMBL2348989)
Affinity DataIC50: 43nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50432397(CHEMBL2348989)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50432397(CHEMBL2348989)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 60 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50432397(CHEMBL2348989)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50432397(CHEMBL2348989)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed