BDBM50433295 CHEMBL2376439

SMILES CC(=O)N[C@@H]1CCc2ccc(Oc3cnc4[nH]cc(C(=O)N[C@H](C5CC5)C(=O)N5CC(C5)C#N)c4n3)cc12

InChI Key InChIKey=KGNIKVYPAXDZAZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50433295   

TargetTyrosine-protein kinase JAK1/JAK2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-induced STAT5a phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 7.41E+3nMAssay Description:Inhibition of JAK1/3 in human PBMC expressing CD3 assessed as inhibition of IL2-induced STAT5a phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 262nMAssay Description:Inhibition of JAK1 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in SF21 cells using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433295(CHEMBL2376439)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed