BDBM50433298 CHEMBL2376440

SMILES CC(=O)N[C@@H]1CCc2ccc(Oc3cnc4[nH]cc(C(=O)N[C@@H](C(=O)N5CC(C5)C#N)C(C)(C)C)c4n3)cc12

InChI Key InChIKey=WZRKPAUVPLLULB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50433298   

TargetTyrosine-protein kinase JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433298(CHEMBL2376440)
Affinity DataIC50: 863nMAssay Description:Inhibition of JAK1 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433298(CHEMBL2376440)
Affinity DataIC50: 446nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in SF21 cells using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433298(CHEMBL2376440)
Affinity DataIC50: 57nMAssay Description:Inhibition of JAK3 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed