BDBM50433301 CHEMBL2376339

SMILES CC(C)NC(=O)c1c[nH]c2ncc(Oc3ccc4CC[C@H](NC(C)=O)c4c3)nc12

InChI Key InChIKey=WISJHPKKVVBBCE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50433301   

TargetTyrosine-protein kinase JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433301(CHEMBL2376339)
Affinity DataIC50: 4.39E+3nMAssay Description:Inhibition of JAK1 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433301(CHEMBL2376339)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in SF21 cells using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433301(CHEMBL2376339)
Affinity DataIC50: 340nMAssay Description:Inhibition of JAK3 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed