BDBM50433843 CHEMBL2382401

SMILES C[C@@H](C(=O)Nc1ccc(cc1)S(=O)(=O)N)SC2=NC(=C(C(=O)N2)C#N)c3ccc(cc3)Cl

InChI Key InChIKey=JDIGFAGHWNBGPU-UHFFFAOYSA-N

Data  5 KI  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50433843   

TargetL-lactate dehydrogenase A chain(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataIC50: 480nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKi:  5nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKi:  9.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50433843(CHEMBL2382401)
Affinity DataKi:  83nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2017
Entry Details Article
PubMed