BDBM50437405 CHEMBL2408778

SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCC(=O)NO

InChI Key InChIKey=SJKCAVNLLOXGJL-UHFFFAOYSA-N

Data  6 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50437405   

TargetHistone deacetylase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of HDAC5 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of HDAC7 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHK(Ac)K(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 86nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 224nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 51nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 231nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataIC50: 19nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorogenic peptide from p53 residues (379 to 382) (RHKK(Ac)) as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)AMCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  0.260nMAssay Description:Inhibition of HDAC1 (unknown origin) by Fluor de Lys based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  138nMAssay Description:Inhibition of c-Src (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  138nMAssay Description:Inhibition of c-Src (unknown origin) after 10 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  504nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50437405(CHEMBL2408778)
Affinity DataKi:  2.35E+3nMAssay Description:Inhibition of c-Abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed