BDBM50438265 CHEMBL2407976

SMILES CC1Oc2c(C)cc(CN3CCN(CC3)c3ccc(cc3)C(=O)NC3CC3)cc2NC1=O

InChI Key InChIKey=ODABPGDGTYGIAU-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50438265   

TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438265(CHEMBL2407976)
Affinity DataIC50: 33nMAssay Description:Inhibition of human PARP1 catalytic activity after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438265(CHEMBL2407976)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438265(CHEMBL2407976)
Affinity DataEC50:  1.00E+5nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed