BDBM50438316 CHEMBL2408613

SMILES Nc1ncc(-c2cnn(c2)[C@H]2CC[C@H](O)CC2)c2c(c(oc12)-c1cccc2nnsc12)-c1cccnc1

InChI Key InChIKey=LTQRMOSYFBRQRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50438316   

TargetAurora kinase B(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438316(CHEMBL2408613)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of aurora B kinase in human HT-29 cells assessed as inhibition of histone H3 S10 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438316(CHEMBL2408613)
Affinity DataIC50: 130nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50438316(CHEMBL2408613)
Affinity DataIC50: 110nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed